HYPERMUTATIONS

Somatic hypermutation - Wikipedia

Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), ...

hypermutations

Hypermutations in gliomas: a potential immunotherapy target.

Discov Med. 2019 Feb;23(125):113-120. Hypermutations in gliomas: a potential immunotherapy target. Finocchiaro G(1), Langella T(1), Corbetta C(1), ...

hypermutations

When Hypermutations and Ageing Enable Artificial Immune Systems ...

4 Apr 2019 ... We first highlight the power and limitations of its distinguishing operators (i.e., hypermutations with mutation potential and ageing) by analysing ...

hypermutations

Detecting hypermutations in viral sequences with an emphasis on G ...

Bioinformatics. 2000 Apr;16(4):400-1. Detecting hypermutations in viral sequences with an emphasis on G --> A hypermutation. Rose PP(1), Korber BT.

hypermutations

Detecting hypermutations in viral sequences with an emphasis on G ...

Abstract. Summary: This program compares sequence sets to a reference sequence, tallies G → A hypermutations, and presents the results in various tables and.

hypermutations

HIV-1 Vif inhibits G to A hypermutations catalyzed by virus ...

11 Oct 2014 ... A Vif mutant with a defect in viral packaging showed a reduced ability to protect the HIV-1 genome from G to A hypermutations.

hypermutations

Analysis of 6912 Unselected Somatic Hypermutations in Human ...

1 Apr 2007 ... Somatic hypermutations (SHMs) in the form of nucleotide substitutions, insertions , and deletions are found throughout the variable regions of Ig ...

hypermutations

G ---> A Hypermutation

4 Jan 2012 ... A G --> A hypermutant is a term given to retroviral proviruses bearing an inordinate number of G --> A transitions, typical examples being given ...

hypermutations

A target selection of somatic hypermutations is regulated similarly ...

22 Mar 2005 ... Abstract. Activation-induced cytidine deaminase (AID) is essential for somatic hypermutations (SHM) and class switch recombination.

hypermutations

Somatic Hypermutation - an overview | ScienceDirect Topics

Somatic hypermutation is a process in which point mutations accumulate in the antibody V-regions of both the heavy and light chains, at rates that are about ...

hypermutations

The Effects of Somatic Hypermutation on Neutralization and Binding ...

21 Nov 2013 ... 30 Dec 2013: Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, et al. (2013) Correction: The Effects of Somatic Hypermutation on ...

hypermutations

hypermutation - Wiktionary

hypermutation (countable and uncountable, plural hypermutations). (uncountable ) Frequent mutation; (countable) The organism or gene that results from such a ...

hypermutations

Different Somatic Hypermutation Levels among Antibody ... - Frontiers

3 May 2019 ... A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes and subsequent somatic hypermutation (SHM).

hypermutations

Molecular Mechanisms of Antibody Somatic Hypermutation | Annual ...

7 Jul 2007 ... AbstractFunctional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation results ...

hypermutations

Somatic hypermutations

20 Jan 2020 ... Somatic hypermutation (SHM) is the mechanism which diversifies the immunoglobulin (IG) repertoire by introducing mutations into rearranged ...

hypermutations

Hypermutations in Gliomas: a Potential Immunotherapy Target ...

23 Feb 2019 ... Hypermutations in tumors are caused by environmental factors, like UV radiations or cigarette smoking, or by germinal mutations affecting ...

hypermutations

Distribution and Nucleotide Biases of the Somatic Hypermutations in ...

3 Nov 2003 ... Previous article in issue: Intranasal Inoculation of Bordetella Bronchiseptica in Mice Induces Long-Lasting Antibody and T-Cell Mediated ...

hypermutations

The Inactive X Chromosome Is Hypermutated in Cancer | Cancer ...

1 Dec 2013 ... Concept: X chromosome hypermutation is specifically observed in female ... Impact: Hypermutation of the inactive X chromosome may be a ...

hypermutations

Conserved Footprints of APOBEC3G on Hypermutated Human ...

Analysis of hypermutation in sequences derived from HIV-1-infected patients for which no parental sequence is available.For an ideal hypermutation analysis, ...

hypermutations

A broad atlas of somatic hypermutation allows prediction of ...

26 Jan 2019 ... Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on ...

hypermutations

Somatic hypermutation - Latest research and news | Nature

How B cell tolerance is retained during somatic hypermutation in germinal centers is incompletely understood. Two studies now show that Foxp3+ regulatory T ...

hypermutations

Hypermutation in Cryptococcus reveals a novel pathway to 5 ...

10 Oct 2019 ... Abstract. Drug resistance is a critical challenge in treating infectious disease. For fungal infections, this issue is exacerbated by the limited ...

hypermutations

Enhancers Improve the AID-Induced Hypermutation in Episomal ...

The induction of somatic hypermutation (SHM) in various cell lines by activation- induced cytidine deaminase (AID) has been used in protein-directed selection, ...

hypermutations

Somatic hypermutation analysis in follicular lymphoma provides ...

Somatic hypermutation analysis in follicular lymphoma provides evidence suggesting bidirectional cell migration between lymph node and bone marrow during ...

hypermutations

Pilot Study of Nivolumab in Pediatric Patients With Hypermutant ...

14 Dec 2019 ... This study is to assess clinical and radiological benefits of treatment with Nivolumab in children with hypermutated cancers, including those ...

hypermutations

Aberrant somatic hypermutation and lymphomagenesis | Blood ...

1 Sep 2003 ... This is a related article to: Aberrant somatic hypermutation in multiple ... B lymphocytes undergoing the somatic hypermutation (SHM) process ...

hypermutations

Hypermutations in porcine respiratory and reproductive syndrome ...

4 Sep 2019 ... Request PDF | Hypermutations in porcine respiratory and reproductive syndrome virus | Porcine reproductive and respiratory syndrome ...

hypermutations

Mutational Analysis of 48G7 Reveals that Somatic Hypermutation ...

24 Jun 2013 ... The monoclonal antibody 48G7 differs from its germline precursor by 10 somatic mutations, a number of which appear to be functionally silent.

hypermutations

Immunoglobulin somatic hypermutation has clinical impact in ...

22 Oct 2019 ... Diffuse large B-cell lymphoma (DLBCL) harbors somatic hypermutation (SHM) in the immunoglobulin heavy chain and light chain variable ...

hypermutations

Somatic Hypermutation of the YAP Oncogene in a Human ...

1 Jul 2019 ... Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma. Xiaomeng Zhang, Jian Zhong Tang, Ismael A. Vergara, ...

hypermutations

IGH and IGK Rearrangement and IGH Somatic Hypermutation ...

IGH and IGK Rearrangement and IGH Somatic Hypermutation Analysis Using Next-generation Sequencing for the Detection of Clonality in High-risk Korean ...

hypermutations

Recombinase-Mediated Cassette Exchange as a Novel Method To ...

11 Oct 2011 ... Activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) of immunoglobulin (Ig) genes. Although a great deal ...

hypermutations

Hypermutation and microsatellite instability in gastrointestinal cancers

19 Dec 2019 ... Hypermutation in cancer can be caused by a variety of mechanisms, including exogenous mutagens and endogenous processes. Exposure to ...

hypermutations

A classification model for G-to-A hypermutation in hepatitis B virus ...

11 Oct 2010 ... ABSTRACT. Motivation: G→A hypermutation is an innate antiviral defense me- chanism, mediated by host enzymes, which leads to the ...

hypermutations

Bcl-6 gene hypermutations in diffuse large B-cell lymphoma of ...

6 Sep 2010 ... Abstract, The presence of the bcl-6 gene hypermutation was studied in 40 Hong Kong Chinese patients with diffuse large B-cell lymphoma.

hypermutations

Abstract 4265: The landscape of somatic hypermutation in human ...

1 Oct 2014 ... Abstract. Somatic hypermutation is present in the tumor genomes of a subset of human cancers. Nevertheless, the extent as well as the ...

hypermutations

BCLL - Clinical: IGH Somatic Hypermutation Analysis, B-Cell ...

Clonal IGHV gene hypermutation status provides important prognostic information for ... Hypermutation of the IGH variable region is strongly predictive of a good ...

hypermutations

Immunology - Adaptive Immunity (B cell Activation, Hypermutation ...

20 Nov 2012 ... http://armandoh.org/ Image: https://docs.google.com/open?id=0B8Ss3- wJfHrpU2NDZnIwZHFBWUE ...

hypermutations

Germline POLE mutation in a child with hypermutated ...

17 Oct 2019 ... Abstract. Ultra-hypermutation (>100 mutations/Mb) is rare in childhood cancer genomes and has been primarily reported in patients with ...

hypermutations

Hypermutated Circulating Tumor DNA: Correlation with Response to ...

1 Oct 2019 ... We sought to investigate the association between hypermutated blood-derived circulating tumor DNA (ctDNA) and checkpoint inhibitor ...

hypermutations

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